The opportunities:

A post-doctoral fellow (PDF) position is available in the research team of Professor Michael Olson, In this position, you will use xenograft and genetically-modified (GM) in vivo models to learn more about the role of Rho signalling in tumour growth and progression, related to previous studies from the Olson lab (e.g. Elife. 2021 Apr 19;10:e61983; Cancer Res. 2018;78:3321; EMBO Mol Med. 2017;9:198; Cancer Cell. 2011;19:776). The research you undertake will employ a variety of genetic, biochemical and imaging based methods that take advantage of the advanced state-of-the-art technical resources available in the Discovery District of downtown Toronto.

In addition to conducting research, the PDF will be expected to take a leadership role in the Olson lab, seek external funding opportunities to support their research, mentor junior members of the lab, and communicate research findings through presentations at scientific conferences and publications in internationally recognized journals. The PDF will have dedicated desk and bench space, and access to infrastructure and financial resources to carry out the proposed research. The PDF will also be encouraged to seek professional development opportunities to benefit the PDF’s personal goals.

Qualifications

The following qualifications and skills are required:

  • PhD (held or to be awarded soon) in a relevant biomedical field (e.g. genetics, biochemistry, biology, immunology, etc.).

  • Experience with GM cancer models

  • Experience with at least some of: fluorescence microscopy, image analysis, immunohistochemistry

  • Ability to conduct independent research, data collection and analysis, and write technical reports, research grant proposals, and peer-reviewed journal articles

  • Excellent interpersonal and communication skills

  • Ability to work in a collaborative and multidisciplinary research group

  • A track record of peer-reviewed published research work

  • Background knowledge of signal transduction

  • Background knowledge of cancer

The following backgrounds would be considered as assets/highly desired:

  • Knowledge and experience in immunology research

  • Knowledge and experience in pre-clinical imaging and therapy

  • Knowledge and experience in data science/analysis

A research assistant position is also available. The research assistant will work under the general direction of the Principal Investigator (PI), and will support the PI, students, and post-doctoral fellows (PDFs) in the laboratory. The research responsibilities will include: management of mouse colonies, genotyping, establishment of breeding strategies, drug/compound administration, tissue sampling for IHC, blood sampling, immunohistochemistry, imaging, and sample preparation for analysis such as western blotting, mass spectrometry or RT-PCR. In addition, experiments will also make use of established and primary cell lines, using methods including biochemistry, western blotting, immunofluorescence and RT-PCR.

Qualifications

The ideal candidate holds a Master’s degree or higher in a relevant scientific discipline, such as genetics, immunology or biochemistry. Interested individuals must demonstrate their expertise in the use of genetically modified mice for the study of cancer or immunology. This position will support research projects undertaken by team members, and may span several different areas of investigation. Familiarity with image acquisition software is highly desired, as is familiarity with common image analysis software programs. Experience with safe lab operations, including all safety procedures, restocking lab supplies and reagents, troubleshooting and the ability to provide effective training and orientation to students and other researchers is essential. The incumbent should be highly computer literate, have excellent interpersonal and communication skills, and be able to work in a collaborative and multidisciplinary research group.

How to apply

Please email your application to Michael Olson at michael.olson@ryerson.ca.

 

Applications should be submitted in PDF or word formats. In the subject line please indicate: “PDF Application” or "RA Application" as appropriate. Applications should include: CV, cover letter, names of up to 3 references. We thank all candidates for their interest, however, only candidates who are invited to an interview will be contacted.